Twipster, an extension for Chrome and Safari, removes all the noise on twitter.com to only deliver the updates from the Tweeps you follow in a minimalist and easy-to-read format.
No more left sidebar. The only “distraction” is the Home, @Connect, and Me tabs at the top of the page.
If you visit your profile page, you will also notice that the Following, Followers, Favorites, and Lists tabs have been moved to the top, and the background picture removed.
To start using Twipster, visit http://jxnblk.com/twipster/.